Pedestrians, who are believed to be anti-racism demonstrators, blocked the M6 motorway following a protest in Coventry, in the West Midlands.
Police said that a group of people walked between Junctions 3 and 2, in Warwickshire, which led to the closure of the road there.
It came on the day of a series of demonstrations which have been sparked by the murder of George Floyd, an unarmed Black man, by police officers in Minneapolis, in the US.
Also, about 1,000 people gathered in Wolverhampton to air their grievances at a Black Lives Matter protest there.
Meanwhile, in Bristol, a statue of a slave trader was torn down by protesters, and thrown into the harbour during a second day of anti-racism and police murders that is still carried out in the UK.
It follows demonstrations that took place in Edinburgh, Belfast, London, Cornwall, and other parts of Britain over the weekend.