Jamaican Elaine Thompson-Herah added Commonwealth 100m gold to her collection in a time of 10.95 seconds.
The five-time Olympic champion was clean away and immediately up on England's Daryll Neita, who ran a personal best 10.90 in the semi-finals, before ending up with bronze.
Para-swimmer Bethany Firth, 26, stormed to Northern Ireland's first gold medal of the Commonwealth Games in the women's S14 200m freestyle final on an unprecedented night for NI swimming.
England's Katarina Johnson-Thompson and Scotland's Eilish McColgan earned hugely popular Commonwealth Games titles on the loudest night yet at Birmingham's Alexander Stadium. Johnson-Thompson's win marks the former world champion's return to the top of an international podium after three years of injury and coaching changes.
She finished on 6,377 points, 144 clear of Northern Ireland's Kate O'Connor, whilst McColgan's victory marks her first major title at the age of 31. Her triumph also follows in the footsteps of her mother Liz, who won the same title at Edinburgh 1986 and Auckland 1990.
Five-time Olympic champion, Thompson-Herah, was clean away and immediately up on England's Daryll Neita - who ran a personal best 10.90 in the semi-finals - outside her. Neita could not make up the deficit and ended with bronze.
Six-time Paralympic champion, Firth, 26, clocked 2:07.02 to finish 1.54 seconds ahead of England's Jessica-Jane Applegate in second. Just an hour later at Sandwell Aquatics Centre, her team-mate Daniel Wiffen took silver in the men's 1500m freestyle to bring NI's medal haul in the pool to three.
Other highlights saw Sri Lanka's Yupun Abeykoon claim her country's first athletics medal at the Games since 1998 by taking bronze in 10.14.
England's Gina Kennedy won a squash gold, after beating Canada's Hollie Naughton 11-7 11-5 12-14 11-5, whilst 73-year-old Dumfries pensioner, Rosemary Lenton, became Scotland's oldest ever Commonwealth Games gold medal winner after helping winning the Para women's pairs bowls.
"I think I am dreaming, to be perfectly honest," Lenton said after linking up with Pauline Wilson to defeat Australia's Cheryl Lindfield and Serena Bonnell 17-5 in the gold-medal match at Leamington Spa's Victoria Park.
On the men’s side, Kenya’s Ferdinand Omanyala claimed gold in the 100m final, Uganda’s Jacob Kiplimo won the 10,000 title, whilst fellow countryman, Victor Kiplangat won the Game’s marathon.