Scientists at the University of Birmingham are to investigate how a chemical found in a common garden plant could be better used to help heart patients.

Dr Davor Pavlovic has been awarded £170,000 by the British Heart Foundation (BHF) to study how different patients respond to digoxin – a chemical found in foxgloves.

Digoxin was first discovered in 1785 by a noted botanist William Withering who lived and worked in Birmingham. It is currently used in medicines to treat patients with a common heart rhythm disorder called atrial fibrillation and heart failure. Digoxin works by slowing the heart rate and reducing the strain placed on the heart muscle.

Recently, there has been debate between doctors about the safety and effectiveness of digoxin because, in some patients, it doesn’t always work as well as expected. But Dr Pavlovic and his team think that they may have discovered why.

Dr Davor Pavlovic, the lead researcher at the University of Birmingham, said: “We have found that a hormone in the blood - called cardiotonic steroids – may interfere with how the body responds to digoxin.

“Levels of cardiotonic steroids in the blood are higher in people with heart disease, but vary from person to person. This could be why digoxin works for some heart patients, but not as well in others.

“In this project we’re going to develop a new laboratory test for measuring cardiotonic steroids in the blood and also study their effect on heart cells in the laboratory.

“We hope that we can then use these results to propose new ways to personalise treatment for patients with atrial fibrillation and heart failure.”

Colleague Professor Wiebke Arlt is the William Withering Chair in Medicine at the University of Birmingham, commemorating the contributions of William Withering. She says “I am excited to work on this project and examine the roles of digoxin and related cardiotonic steroids, thereby going full circle back to William Withering.”

If successful, this test will then be applied to patients with atrial fibrillation and heart failure enrolled in the RATE-AF clinical trial led by Dr Dipak Kotecha.  The RATE-AF clinical trial is funded by the National Institute of Health Research (NIHR), which supports research within the National Health Service (NHS) in order to improve the health of the nation.

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, added:

“Atrial fibrillation and heart failure can severely impair quality of life of people with these conditions, and current treatment options can be unpredictable.

“By funding this work we hope to answer some fundamental questions about why digoxin works less well in some patients than others. It is only because of the generous support of the public that we can invest in projects like this which seek to improve the treatments and lives of heart patients.

More than half a million people are living with heart failure, and at least a million people have been diagnosed with atrial fibrillation in the UK. By finding answers to important research questions, the British Heart Foundation is working to ensure that patients receive the best treatments possible. None of this would be possible without people’s generous donations in the fight against heart disease.

Veteran Army Lance Corporal and Invictus Games athlete, Clive Smith, is this week taking on a new sporting challenge.

The 38 year old has been selected for one of two Help for Heroes teams who will be taking part in an exhibition match at the first ever Wheelchair Rugby Quad Nations tournament.

Clive, from Wolverhampton, lost both of his legs above the knee in a blast in Afghanistan in 2010. Four years on he was part of the inaugural Invictus Games in London and also brought home a silver medal in wheelchair rugby from last year’s Games in Toronto.

“Since the Invictus Games I have been building on my upper body strength with resistance weight training at my local gym 3 times a week. I also attend training days with a local wheelchair rugby team. I embrace any opportunity to play wheelchair rugby. I love the sport. I love the team atmosphere. And I must admit I love the ruthlessness of the sport! It’s hard core; just what I like”.

Taking place from 9^th – 11^th March 2018 the Wheelchair Rugby Quad Nations is an international tournament that will feature four wheelchair rugby teams; all ranked within the top 5 in the World. For three days the Leicester Arena will play host to World Champions and Paralympic Gold, Silver and Bronze medallist teams from around the globe. Help for Heroes is proud to have put together two teams who will play an exhibition match before the Great Britain versus Japan match on the first night of the tournament.

Steve Schollar, Head of Recovery for the East and Midlands, said: “Sport plays a big part in the recovery journey for our Veterans and Service Personnel who have been wounded, injured or sick as a result of their service. It gives them a second chance at life; enabling them to regain their purpose and sense of confidence. We encourage anyone that might want to try sport for the first time post injury to be inspired by these athletes and they too could experience the power of sport in their day to day lives.”

Tickets start at just £5 with special offers available for groups and families. Tickets are available from http://www.wrquadnations.com along with a full match schedule.

RSPCA officers were really concerned after receiving reports of a swan which had been beheaded in Warrington. But, they had a pleasant surprise when they arrived to find a plastic model which was broken at the neck!

An upset woman contact the animal welfare charity on February 22 after spotting the swan laid out on the gravel at Europa Boulevard in Westbrook.

RSPCA inspector Claire Fisher visited the scene and quickly realised all wasn’t as it first seemed…

“When the woman called us she said the bird was collapsed with the neck stretched out and that it couldn’t move,” Inspector Fisher said.

“She thought the swan had been hit by a car before collapsing on some gravel beside a pond.

“I met the site manager on Gemini Business Park and we soon realised no veterinary treatment would be necessary - as the bird was a plastic model!

“We can only guess that a driver had seen the swan from the road - which was some distance - where it could have easily been mistaken for a real bird!

“He arranged some emergency treatment for the beheaded statue - some silicone and a screw or two - before returning her to her mate!”

The RSPCA takes all complaints of animal cruelty seriously and looks into all reports. However, sometimes the charity does discover reports aren’t always quite what they may seem.

Inspector Fisher added: “We all had a laugh about this one and, to be honest, were just relieved there wasn’t a swan that had suffered an awful death.”

To report animal cruelty or a welfare concern to the RSPCA, call the charity’s 24-hour hotline on 0300 1234 999.

Severn Trent will be paying compensation to any customers who were without water for more than 12 continuous hours, or for more than 15 hours of intermittent supply, after the freezing temperatures and sudden thaw caused supply issues across the Midlands over recent days.

A payment of £30, which is roughly the same as having a month free on the average combined water and waste bill, will be offered to all homes affected so customers don’t need to do anything.

Sarah Bentley, Chief Customer Officer at Severn Trent, said: “We’re incredibly sorry for the disruption which was caused by a huge number of bursts that put intense pressure on our water network.

“Our teams have faced an unprecedented number of leaks since the cold weather began. While we had extra teams in place working round the clock, and have hundreds of people out and about fixing bursts, we know that some customers were without water, and I really can’t apologise enough for that.

“While some customers are seeing water coming and going, the situation is much improved so we wanted to let people know about compensation.

“So, we’ll be compensating the people and families who were without water for 12 continuous hours or for more than 15 hours of intermittent supply with a deduction from their bill, and, once again, we’re just so sorry for the inconvenience this week.”

Customers across the Midlands were affected by the huge increase in bursts caused by the sudden thaw after the Beast from the East. We’ve been working round the clock, and have brought in additional teams from outside the organisation to help fix leaks, ramped up production at our treatment works, and used our tanker fleet to keep on vital services such as hospitals. In addition, a number of bottle drops were organised in key locations and the company hand-delivered water to vulnerable customers.

Domestic customers who will be receiving compensation do not need to do anything and will be contacted in the coming weeks. We’re always happy to discuss compensation claims from anyone who’s been affected on a case by case basis.

We’ll also be working with business customers and their retailers who were also affected.

Commonwealth Day Message by Her Majesty The Queen, Head of the Commonwealth We all have reason to give thanks for the numerous ways in which our lives are enriched when we learn from others. Through exchanging ideas, and seeing life from other perspectives, we grow in understanding and work more collaboratively towards a common future. There is a very special value in the insights we gain through the Commonwealth connection; shared inheritances help us overcome difference so that diversity is a cause for celebration rather than division.

We shall see this in action at the Commonwealth Heads of Government Meeting which takes place in the United Kingdom next month, bringing together young people, business and civil society from across the Commonwealth.

These gatherings are themselves fine examples of how consensus and commitment can help to create a future that is fairer, more secure, more prosperous and sustainable. Having enjoyed the warm hospitality of so many Commonwealth countries over the years, I look forward to the pleasure of welcoming the leaders of our family of 53 nations to my homes in London and Windsor.

Sport also contributes to building peace and development. The excitement and positive potential of friendly rivalry will be on display next month as we enjoy the Commonwealth Games on the Gold Coast, Australia. Contributing to the success of the Games, alongside athletes and officials, will be thousands of volunteers.

Voluntary effort, by people working as individuals, in groups or through larger associations, is so often what shapes the Commonwealth and all our communities. By pledging to serve the common good in new ways, we can ensure that the Commonwealth continues to grow in scope and stature, to have an even greater impact on people’s lives, today, and for future generations.

Commonwealth Day Message by The Rt Hon Patricia Scotland QC, Commonwealth Secretary-General Never before in the history of our family of nations has there been such a remarkable season of gatherings as that heralded by Commonwealth Day 2018.

Over coming weeks at the Commonwealth Heads of Government Meeting and associated forums, leaders and representatives of the people in all 53 of our member countries will assemble to work and plan together. We will share and learn from one another, and be motivated to ever greater heights of endeavour and achievement.

There will also be the Commonwealth Games, with compelling scenes of athletic prowess, tenacity and triumph. Huge new audiences worldwide will deepen in understanding of what the Commonwealth is, what it does, and how it brings positive change for the good of all.

An example of this is the Commonwealth Blue Charter currently being developed. By agreeing to protect the health of oceans and marine life, and to use the precious resources they yield in responsible and sustainable ways, we will be sharing more fairly the benefits they bestow, and preserving these for future generations.

Wherever we live – on island or coast, or inland where streams and rivers flow to the sea – our actions and the way we live affects life in the ocean. In turn, the health of the ocean affects our own wellbeing, our weather, our food, our trade and our prosperity. Industrial and domestic waste pollutes great rivers and their tributaries, or flows directly into the sea. Plastic and other toxic waste materials poison the ocean, which belongs to us all and is vital to our common future.

Just as we work together in the Commonwealth to preserve the health of the ocean, we cooperate in many other ways for the common good. Our member countries have committed to nurture and protect democracy, development and respect for diversity so that people of all communities can live safer and healthier lives, and share in the fruits of prosperity. This includes preventing greed and corruption, unfairness, or partisan discord from poisoning politics and public life.

We work together to achieve this by creating channels through which good ideas and clever ways of doing things flow from the governments and people of all our countries into a continually renewed and refreshed Commonwealth ocean of knowledge. It is an ecosystem of experience and expertise in which all give and all gain.

Through our ‘Faith in the Commonwealth’ project, we draw wisdom and insights from secular streams of thought, and from the many communities and traditions that are the sea of faith. Such resources and riches add to all that we celebrate on Commonwealth Day, and they are indeed treasures to be cherished and shared.

There are opportunities for each and every one of us as members of the worldwide Commonwealth family to become involved. With our fellow citizens, we live, learn, work and play in countries set in every continent and ocean – all 2.4 billion of us, representing a glorious spectrum of diversity and talent. It is by living and working for the good of one another, towards a common future, that we build our Commonwealth.

Community housing projects and charities are being urged to put their case forward as Nationwide - the UK’s biggest building society - makes £250,000 available to help make a difference across communities in the West Midlands.

The Society is inviting applications for grants of up to £50,000 that have the potential to strengthen communities and help make a difference in local areas. Projects could range from innovative new housing, improving rented accommodation conditions, to supporting the most vulnerable.

Applications will be accepted from across west and central areas of the UK, including the following areas: Shropshire, Herefordshire, Worcestershire, Gloucestershire and West Midlands areas of Birmingham.

John Worthy, Nationwide’s Area Director for the West Midlands, said: “As a building society, ensuring that everyone has a place fit to call home is at the heart of what we do. Nationwide was founded to help people save and borrow money for land and materials to build their own homes. One hundred and thirty years on, we still have the same core purpose - helping people into homes of their own.

“We recognise there is a housing crisis, resulting in many people living in unsuitable, insecure or unaffordable accommodation. So, we are delighted to award £250,000 to communities within the West Midlands to support housing projects and make a real difference.”

Nationwide members will get a final say on which projects are supported in their local communities and a Community Board, which is comprised of members, employees, housing charities and experts, has been appointed.  The Board will review all grant applications and put forward a number of local projects to a member vote. Nationwide members will then be able to vote, in branch or online, for a shortlist of charities to be awarded up to a maximum of £50,000. The Board and Nationwide branches within the region will also be providing time, contacts and expertise to these charities.

As part of the Society’s new social investment strategy programme, to provide everyone a place fit to call home, Nationwide plans to roll this initiative out across the UK during 2018, providing a £4million annual fund for community housing initiatives and charities – helping make a difference to communities up and down the country.  There has been £270,000 already awarded to nine different housing charities and organisations in the north of England this year.

Nationwide is now inviting applications for housing community projects in the West Midlands.